銆€銆€閰跺弽鎳�(y墨ng)鍕�(d貌ng)鍔涘(xu茅)

銆€銆€閰朵績鍙嶆噳(y墨ng)鐨勯€熷害鍙栨焙浜庡簳鐗╂績搴�銆侀叾婵冨害銆丳H銆佹韩搴�銆佹縺鍕�(d貌ng)鍔戝拰鎶戝埗鍔戠瓑銆�

銆€銆€1銆佸簳鐗╂績搴�

銆€銆€1)鍦ㄥ簳鐗╂績搴﹁純浣庢檪(sh铆)锛屽弽鎳�(y墨ng)閫熷害闅ㄥ簳鐗╂績搴︾殑澧炲姞鑰屼笂鍗�锛屽姞澶у簳鐗╂績搴�锛屽弽鎳�(y墨ng)閫熷害瓒ㄧ珐锛屽簳鐗╂績搴﹂€�(j矛n)涓€姝ュ楂橈紝鍙嶆噳(y墨ng)閫熷害涓嶅啀闅ㄥ簳鐗╂績搴﹀澶ц€屽姞蹇�锛岄仈(d谩)鏈€澶у弽鎳�(y墨ng)閫熷害锛屾鏅�(sh铆)閰剁殑娲绘€т腑蹇冭搴曠墿椋藉悎銆�

銆€銆€2)绫虫皬鏂圭▼寮�

銆€銆€V=Vmax[S]/Km+[S]

銆€銆€a.绫虫皬甯告暩(sh霉)Km鍊肩瓑浜庨叾淇冨弽鎳�(y墨ng)閫熷害鐐烘渶澶ч€熷害涓€鍗婃檪(sh铆)鐨勫簳鐗╂績搴︺€�

銆€銆€b.Km鍊兼剤灏�锛岄叾鑸囧簳鐗╃殑瑕拰鍔涙剤澶с€�

銆€銆€c.Km鍊兼槸閰剁殑鐗瑰緛鎬у父鏁�(sh霉)涔嬩竴锛屽彧鑸囬叾鐨勭祼(ji茅)妲�(g貌u)銆侀叾鎵€鍌寲鐨勫簳鐗╁拰鍙嶆噳(y墨ng)鐠�(hu谩n)澧冨婧害銆丳H銆侀洟瀛愬挤(qi谩ng)搴︽湁闂�(gu膩n)锛岃垏閰剁殑婵冨害鐒￠棞(gu膩n)銆�

銆€銆€d.Vmax鏄叾瀹屽叏琚簳鐗╅＝鍜屾檪(sh铆)鐨勫弽鎳�(y墨ng)閫熷害锛岃垏閰舵績搴﹀憟姝ｆ瘮銆�

銆€銆€2銆侀叾婵冨害

銆€銆€鍦ㄩ叾淇冨弽鎳�(y墨ng)绯荤当(t菕ng)涓�锛岀暥(d膩ng)?sh霉)瀛滈鑸涘嵈锜犺煪顑篰閰舵績搴︼紝浣块叾琚簳鐗╅＝鍜屾檪(sh铆)锛屽弽鎳�(y墨ng)閫熷害鑸囬叾鐨勬績搴︽垚姝ｆ瘮闂�(gu膩n)绯�銆�

銆€銆€3銆佹韩搴�

銆€銆€婧害灏�(du矛)閰朵績鍙嶆噳(y墨ng)閫熷害鍏锋湁闆欓噸褰遍熆銆傚崌楂樻韩搴︿竴鏂归潰鍙姞蹇叾淇冨弽鎳�(y墨ng)閫熷害锛屽悓鏅�(sh铆)涔熷鍔犻叾鐨勮畩鎬с€傞叾淇冨弽鎳�(y墨ng)鏈€蹇檪(sh铆)鐨勭挵(hu谩n)澧冩韩搴︾ū鐐洪叾淇冨弽鎳�(y墨ng)鐨勬渶閬╂韩搴�銆傞叾鐨勬椿鎬ч洊鐒堕毃婧害鐨勪笅闄嶈€岄檷浣�锛屼絾浣庢韩涓€鑸笉浣块叾鐮村銆�

銆€銆€閰剁殑鏈€閬╂韩搴︿笉鏄叾鐨勭壒寰佹€у父鏁�(sh霉)锛屽畠鑸囧弽鎳�(y墨ng)閫�(j矛n)琛岀殑鏅�(sh铆)闁撴湁闂�(gu膩n)銆�

銆€銆€4銆丳H

銆€銆€閰舵椿鎬у彈鍏跺弽鎳�(y墨ng)鐠�(hu谩n)澧冪殑PH褰遍熆锛屼笖涓嶅悓鐨勯叾灏�(du矛)PH鏈変笉鍚岃姹�锛岄叾娲绘€ф渶澶х殑鏌愪竴PH鍊肩偤閰剁殑鏈€閬㏄H鍊硷紝濡傝儍铔嬬櫧閰剁殑鏈€閬㏄H绱勭偤1.8锛岃倽绮炬皑閰搁叾鏈€閬㏄H鐐�9.8锛屼絾澶氭暩(sh霉)閰剁殑鏈€閬㏄H鎺ヨ繎涓€с€�

銆€銆€鏈€閬㏄H涓嶆槸閰剁殑鐗瑰緛鎬у父鏁�(sh霉)锛屽畠鍙楀簳鐗╂績搴�銆佺珐娌栨恫鐨勭ó椤炶垏婵冨害銆佷互鍙婇叾鐨勭磾搴︾瓑鍥犵礌褰遍熆銆�

銆€銆€5銆佹縺娲诲姂

銆€銆€浣块叾鐢辩劇娲绘€ф垨浣块叾娲绘€у鍔犵殑鐗╄唱(zh矛)绋辩偤閰剁殑婵€娲诲姂锛屽ぇ澶氱偤閲戝爆闆㈠瓙锛屼篃鏈夎ū澶氭湁姗�(j墨)鍖栧悎鐗╂縺娲诲姂銆傚垎鐐哄繀闇€婵€娲诲姂鍜岄潪蹇呴渶婵€娲诲姂銆�

銆€銆€6銆佹姂鍒跺姂

銆€銆€鍑¤兘浣块叾鐨勫偓鍖栨椿鎬т笅闄嶈€屼笉寮曡捣閰惰泲鐧借畩鎬х殑鐗╄唱(zh矛)绲�(t菕ng)绋辩偤閰剁殑鎶戝埗鍔�銆傚ぇ澶氳垏閰剁殑娲绘€т腑蹇冨収(n猫i)銆佸蹇呴渶鍩哄湗(tu谩n)鐩哥祼(ji茅)鍚�锛屽緸鑰屾姂鍒堕叾鐨勫偓鍖栨椿鎬�?锛熺厼璀冩?/p>

銆€銆€1)涓嶅彲閫嗘€ф姂鍒跺姂锛氫互鍏卞児(ji脿)閸佃垏閰舵椿鎬т腑蹇冧笂鐨勫繀闇€鍩哄湗(tu谩n)鐩哥祼(ji茅)鍚堬紝浣块叾澶辨椿銆傛绋姂鍒跺姂涓嶈兘鐢ㄩ€忔瀽銆佽秴婵剧瓑鏂规硶鍘婚櫎銆傚張鍙垎鐐猴細

銆€銆€a.灏堜竴鎬ф姂鍒跺姂锛氬杈�(n贸ng)钘ユ暤鐧捐煵銆佹暤鏁电晱绛夋湁姗�(j墨)纾峰寲鍚堢墿鑳界壒姘戝湴鑸囪喗鍫块叝閰舵椿鎬т腑蹇冪挡姘ㄩ吀娈樺熀鐨勭茎鍩虹祼(ji茅)鍚�锛屼娇閰跺け娲�锛岃В纾峰畾鍙В闄ゆ湁姗�(j墨)纾峰寲鍚堢墿灏�(du矛)缇ュ熀閰剁殑鎶戝埗浣滅敤銆�

銆€銆€b.闈炲皥涓€鎬ф姂鍒跺姂锛氬浣庢績搴︾殑閲嶉噾灞洟瀛愬姹為洟瀛愩€侀妧闆㈠瓙鍙垏閰跺垎瀛愮殑宸板熀绲�(ji茅)鍚�锛屼娇閰跺け娲�锛屼簩宸板熀涓欓唶鍙В姣�?锛涚槣W(xu茅)姣掓埃璺槗澹埃鏄竴绋惈鐮风殑鍖栧悎鐗╋紝鑳芥姂鍒堕珨鍏�(n猫i)鐨勫钒鍩洪叾鑰屼娇浜虹暅涓瘨銆�

銆€銆€2)鍙€嗘€ф姂鍒跺姂锛氶€氬父浠ラ潪鍏卞児(ji脿)閸佃垏閰跺拰(鎴�)閰�-搴曠墿寰�(f霉)鍚堢墿鍙€嗘€х祼(ji茅)鍚�锛屼娇閰舵椿鎬ч檷浣庢垨娑堝け銆傞噰鐢ㄩ€忔瀽鎴栬秴婵剧殑鏂规硶鍙皣鎶戝埗鍔戦櫎鍘�锛屼娇閰舵仮寰�(f霉)娲绘€�?锛熺厼璀冩?/p>

銆€銆€a.绔�(j矛ng)鐖€ф姂鍒跺姂锛氳垏搴曠墿绔�(j矛ng)鐖叾鐨勬椿鎬т腑蹇�锛屽緸鑰岄樆绀欓叾鑸囧簳鐗╃祼(ji茅)鍚堝舰鎴愪腑闁撶敘(ch菐n)鐗┿€傚涓欎簩閰稿皪(du矛)鐞ョ弨閰歌劔姘叾鐨勬姂鍒朵綔鐢�;纾鸿兒椤炶棩鐗╃敱浜庡寲瀛�(xu茅)绲�(ji茅)妲�(g貌u)鑸囧皪(du矛)姘ㄥ熀鑻敳閰哥浉浼�锛屾槸浜屾矮钁夐吀鍚堟垚閰剁殑绔�(j矛ng)鐖姂鍒跺姂锛屾姂鍒朵簩姘憠閰哥殑鍚堟垚;瑷卞鎶椾唬璎濈殑鎶楃檶钘ョ墿锛屽姘ㄧ敳铦跺懁(MTX)銆�5-姘熷翱鍢у暥(5-FU )銆�6-宸板熀鍢屽懁(6-MP)绛�锛屽咕涔庨兘鏄叾鐨勭(j矛ng)鐖€ф姂鍒跺姂锛屽垎鍒ユ姂鍒跺洓姘憠閰�銆佽劔姘ц兏鑻烽吀鍙婂槍鍛ゆ牳鑻烽吀鐨勫悎鎴�銆�

銆€銆€Vmax涓嶈畩锛孠m鍊煎澶�

銆€銆€b.闈炵(j矛ng)鐖€ф姂鍒跺姂锛氳垏閰舵椿鎬т腑蹇冨鐨勫繀闇€鍩哄湗(tu谩n)绲�(ji茅)鍚�锛屼笉褰遍熆閰惰垏搴曠墿鐨勭祼(ji茅)鍚�锛岄叾鍜屽簳鐗╃殑绲�(ji茅)鍚堜篃涓嶅奖闊胯垏鎶戝埗鍔戠殑绲�(ji茅)鍚�銆�

銆€銆€Vmax闄嶄綆锛孠m鍊间笉璁�

銆€銆€c.鍙嶇(j矛ng)鐖€ф姂鍒跺姂锛氬儏鑸囬叾鍜屽簳鐗╁舰鎴愮殑涓枔鐢�(ch菐n)鐗╃祼(ji茅)鍚�锛屼娇涓枔鐢�(ch菐n)鐗╃殑閲忎笅闄嶃€�

銆€銆€Vmax銆� Km鍧囬檷浣�

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